Ongoing R & D


Ongoing R & D


ARTSENS-Mobile
have to get datas
Heartache
The HeartAche project aims at early detection and prevention of coronary artery disease and detection of acute cardiac events. The project aims at developing a functioning cardiovascular monitoring ecosystem consisting of smart devices, add-on sensor modules for smart devices and a backend system. For end users, the visible part of the ecosystem would naturally be the smart device, which would give a comprehensible interpretation of measured data (i.e. vascular condition, cardiac motion, cardiac time intervals, and cardiovascular motion). The project aims to gather a comprehensive picture of the cardiovascular health condition by combining sonography, seismocardiography, electrocardiography and ballistocardiography signals to capture various facets of cardiovascular health

Completed projects


Pre-operative plate contouring technology
HTIC started developing an affordable technology solution to perform accurate contouring for creating patient specific pre-contoured surgical plates, for use in reconstructive surgeries in 2014. The technology is targeted towards mitigating the barriers of time, skill and effort required to perform patient specific plate contouring as per current clinical practice of manual, on the table contouring that is often performed during the surgery. In 2014-2015, HTIC developed a full-fledged technology platform, that included a software platform for converts patient’s CT images into patient’s anatomy and generates optimised instructions for performing patient specific plate contouring, and a hardware component that includes intuitive, and easy-to-operate tools for accurate plate contouring. Extensive development of the basic software into a comprehensive management tool for plate contouring was performed this year. The software was based on the 3D Slicer platform, which was customised to develop a standalone application, which could be deployed on a desktop/laptop computer. The technology was transferred to an industrial partner post the development, for clinical verification and validation
Cervical cancer screening
Over 366 million women in India are at risk of cervical cancer. The Pap smear test can detect cervical cancer early and hence is a widely used method for population level cervical cancer screening. Becton Dickinson (BD) has developed a technology platform for cervical cancer screening using liquid based cytology (LBC). But there are not enough cytologists and pathologists available in India to interpret LBC test results. HTIC collaborated with BD to conduct a multi-centric study to evaluate the feasibility and appropriateness of LBC in cervical cancer screening in resource-constrained settings. The study was performed in PGIMER Chandigarh and Malabar Cancer Center Thalassery
Neonatal transport unit
A neonatal transport unit is used for safe transfer of new born from the birth place, typically a primary health care centre, to a secondary or tertiary healthcare facility, in case of any medical emergency. The existing neonatal ambulance, operated by EMRI, is a retrofit design and hence has scope for improved space utilisation and better ergonomics. HTIC is currently developing designs for a custom built neonatal transport unit to address the above limitations. Specific design innovations to allow easy loading of the incubator into the vehicle and reduce vibration endured by the neonate in transport are currently under development
AMD Screening
HTIC-Forus partnership for developing AMD screening analytics into the 3nethra ophthalmic screening device
Remote ICU monitoring
Intensive care units (ICU) require specially trained personnel for effective care delivery round the clock. The high intensity nature of ICU se􀀽ng puts strain on personnel to provide timely care and poses challenges to efficient management of clinical human resources. HTIC, along with Sasken, has developed an intelligent solution for continuous monitoring of patient and clinically relevant data from multiple equipment. The system utilises a network of strategically located phone-based cameras, to capture relevant vital parameters and clinically significant data. This technology provides a cost effective, robust and reliable solution for continuous monitoring of ICU patients. The remote monitoring also improves infection control, a critical quality parameter in ICU. The technology is was piloted in Mehta Children Hospital, Chennai
Smartphone based pulse-oximetry
Non-invasive estimates of blood oxygen saturation are essential to evaluate functional effectiveness of cardio-pulmonary systems. Pulse oximeters monitor the amount of oxygen carried by the arterial blood. The technology has largely remained in the form of dedicated devices, for both clinical as well as home-health applications. HTIC has partnered with Tata Elxsi in developing a smart phone based pulse oximeter. The device uses a mobile app and an integrated, inexpensive hardware add-on to perform clinically accurate blood oxygen saturation measurement. Our proprietary and extensively validated mathematical model of the underlying physics of blood oxygen saturation converts a smart phone to an accurate pulse oximeter, without extensive calibration

List of Publications


ARTSENS

Journal articles

  1. Sahani, A. K.; Joseph, J.; Radhakrishnan, R., Sivaprakasam, M., “Automatic Measurement of End-Diastolic Arterial Lumen Diameter in ARTSENS”, Accepted for publication in ASME Journal of Medical Devices, 2015
  2. Joseph, J.; Radhakrishnan, R., Kusmakar, S.; Thrivikraman, A.; Sivaprakasam, M., “Technical validation of ARTSENS – An image free device for evaluation of vascular stiffness,” in IEEE Journal of Translational Engineering in Health and Medicine, vol.3, no. 1, pp.1-13, Dec. 2015
  3. Sahani, A. K.; Shah, M.; Joseph, J.; Sivaprakasam, M., “Carotid and Jugular Classification in ARTSENS,” To appear in IEEE Journal of Biomedical and Health Informatics, 2015, doi: 10.1109/JBHI.2015.2403283
  4. Sahani, A. K.; Shah, M.; Joseph, J.; Radhakrishnan, R., Sivaprakasam, M., “An Imageless Ultrasound Device to Measure Local and Regional Arterial Stiffness,” To appear in IEEE Transactions on Biomedical Circuits and Systems, 2015, doi: 10.1109/TBCAS.2015.2394468
  5. Sahani, A. K.; Joseph, J.; Sivaprakasam, M., "Evaluation of the algorithm for automatic identification of the common carotid artery in ARTSENS", Physiology Measurement, vol. 35, no. 7, pp. 1299-1317, 2014
  6. J. Joseph and V. Jayashankar, “A Virtual Instrument for Automated Measurement of Arterial Compliance,” Journal of Medical Devices, vol. 4, no. 4, p. 045004, 2010.

Conference papers
  1. Joseph, J.; Thrivikraman, A.; Radhakrishnan, R., Sivaprakasam, M., “ARTSENSTouch – A Portable Device for Evaluation of Carotid Artery Stiffness,” To appear in 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
  2. Ganesh, T.; Bhikkaji, B.; Joseph, J.; Sivaprakasam, M., “Sparse Models for determining Arterial Dynamics,” To appear in IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) 2015
  3. Sahani, A. K.; Ravi, V.; Sivaprakasam, M., “Automatic Estimation of Carotid Arterial Pressure in ARTSENS,” Proc. 11th IEEE India Conference, INDICON 2014
  4. Shah, M.; Joseph, J.; Sivaprakasam, M., “Ultrasound Signal Quality Parameterization for Image-free Evaluation of Arterial Stiffness,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  5. Joseph, J.; Arya Sree, T.; Boobalan, C.; Shah, M; Sivaprakasam, M., “Image-free evaluation of carotid artery stiffness using ARTSENS: A repeatability study,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  6. Sahani, A. K.; Shah, M.; Joseph, J.; Sivaprakasam, M., “An Improved Method for Detection of Carotid Walls in ARTSENS,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  7. Shah, M; Joseph, J.; Sivaprakasam, M., “Vascular Compliance Probe with Integrated ECG for Imagefree Evaluation of Arterial Stiffness”, 2014 IEEE International Symposium on Circuits and Systems, 1-5 June 2014
  8. Sahani, A. K.; Joseph, J.; Sivaprakasam, M., "Automatic measurement of lumen diameter of carotid artery in a-mode ultrasound," Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, vol., no., pp.3873,3876, 3-7 July 2013
  9. Joseph, J; Thomas, E. A.; Sivaprakasam, M.; Suresh, S., “ARTSENS-An image-free system for non invasive evaluation of arterial compliance,” in Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, 2013, pp. 4054–4057, 3-7 July 2013
  10. Sahani, A. K.; Joseph, J.; Sivaprakasam, M., "Automated system for imageless evaluation of arterial compliance," Engineering in Medicine and Biology Society (EMBC), 2012 34th Annual International Conference of the IEEE, vol., no., pp.227,231, 28 Aug.-1 Sept. 2012
  11. J. Joseph, J. Venkataraman, V. J. Kumar, and S. Suresh, “Non-invasive estimation of arterial compliance,” in Instrumentation and Measurement Technology Conference (I2MTC), 2011 IEEE, 2011, pp. 1–5
  12. J. Joseph, V. Jayashankar, and V. J. Kumar, “A PC based system for non-invasive measurement of carotid artery compliance,” in Instrumentation and Measurement Technology Conference, 2009. I2MTC’09. IEEE, 2009, pp. 680–685
  13. J. Joseph and V. Jayashankar, “An improved echo tracking algorithm for arterial distensibility measurements,” in Biomedical and Pharmaceutical Engineering, 2009. ICBPE’09. International Conference on, 2009, pp. 1–5
  14. J. Joseph and V. Jayashankar, “Virtual instrument for ultrasound signal processing,” presented at the Ninth National Conference on Technology Trends (NCTT08), Trivandrum, 2008, pp. 242–245
  15. J. Joseph and V. Jayashankar, “A virtual instrument for real time in vivo measurement of carotid artery compliance,” in Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE, 2008, pp. 2281–2284

OASIS

Journal articles

  1. Mukherjee, B.; George, B.; Sivaprakasam, M., "A Multi-Electrode Electric Field Based Sensing System for Ophthalmic Anesthesia Training," To appear in IEEE Transactions on Biomedical Circuits and Systems, doi: 10.1109/TBCAS.2014.2356205
  2. Mukherjee, B.; George, B.; Sivaprakasam, M., "An Ophthalmic Anesthesia Training System Using Integrated Capacitive and Hall Effect Sensors," Instrumentation and Measurement, IEEE Transactions on, vol. 63, no.5, pp. 1153 – 1162, 2014, doi: 10.1109/TIM.2013.2296413

Conference papers
  1. Mukherjee, B.; George, B.; Sivaprakasam, M., “Simple Measurement Scheme for Multiple Capacitors and its Application to an Ophthalmic Anesthesia Training System,” To appear in IEEE International Instrumentation and Measurement Technology Conference (I2MTC) 2015
  2. Mukherjee, B.; George, B.; Sivaprakasam, M., "Syringe injection rate detector employing a dual hall-effect sensor configuration,” Engineering in Medicine and Biology Society (EMBC), 2013 Annual International Conference of the IEEE, vol., no., pp.4734-4737, 3-7 July 2013
  3. Mukherjee, B.; George, B.; Sivaprakasam, M., "An efficient capacitive sensing scheme for an ophthalmic regional anesthesia training system,” Engineering in Medicine and Biology Society (EMBC), 2013 Annual International Conference of the IEEE, vol., no., pp.884-897, 3-7 July 2013
  4. Mukherjee, B.; George, B.; Sivaprakasam, M., "An intelligent ophthalmic regional anesthesia training system based on capacitive sensing," Instrumentation and Measurement Technology Conference (I2MTC), 2013 IEEE International , vol., no., pp.889,893, 6-9 May 2013
  5. Mukherjee, B.; George, B.; Sivaprakasam, M., "A Hall Effect sensor based syringe injection rate detector," Sensing Technology (ICST), 2012 Sixth International Conference on , vol., no., pp.450,453, 18-21 Dec. 2012
  6. Mukherjee, B.; George, B.; Sivaprakasam, M.; Venkatakrishnan, J., “Eye-POD: A novel simulation platform for regional orbital block training,” in 3rd World Congress on Ophthalmic Anesthesia, May 2012
  7. Mukherjee, B.; George, B.; Sivaprakasam, M.; Jagadeesh Kumar, V.; Venkatakrishnan, J., "A capacitive array sensing based training system for ophthalmic anesthesia," Sensing Technology (ICST), 2011 Fifth International Conference on , vol., no., pp.623,627, Nov. 28 2011-Dec. 1 2011

Eye-PAC

  1. Sundaresan V, Ram K, Selvaraj K, Joshi N, and Sivaprakasam M., “Adaptive Super-Candidate Based Approach for Detection and Classification of Drusen on Retinal Fundus Images,” In: Chen X, Garvin MK, Liu J, Trucco E, Xu Y, editors. Proceedings of the Ophthalmic Medical Image Analysis Second International Workshop, OMIA 2015, Held in Conjunction with MICCAI 2015, p. 81-88
  2. Ramaswamy A, Ram K, Joshi N, and Sivaprakasam M: A Polar Map Based Approach Using Retinal Fundus Images for Glaucoma Detection. In: Chen X, Garvin MK, Liu J, Trucco E, Xu Y, editors. Proceedings of the Ophthalmic Medical Image Analysis Second International Workshop, OMIA 2015, Held in Conjunction with MICCAI 2015, p.145-152
  3. Sundaresan V., Ram K., Joshi N., Sivaprakasam M., Gandhi R., “Computer-assisted grading of diabetic macular edema on retinal color fundus images,” To appear in 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
  4. Gupta G., Ram K., Kulasekaran S., Joshi N., Sivaprakasam M., Gandhi R., “Computer-assisted identification of proliferative diabetic retinopathy in color retinal images,” To appear in 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
  5. Sundaresan V., Ram K., Joshi N., Sivaprakasam M., Gandhi R., “Integrated approach for accurate localization of optic disc and macula,” In: Chen X, Garvin MK, Liu JJ editors.Proceedings of the Ophthalmic Medical Image Analysis First International Workshop, OMIA 2014, Held in Conjunction with MICCAI 2014, p. 97-104
  6. Gupta G., Ram K., Kulasekaran S., Joshi N., Sivaprakasam M., Gandhi R., “Detection of retinal hemorrhages in the presence of blood vessels,” In: Chen X, Garvin MK, Liu JJ editors. Proceedings of the Ophthalmic Medical Image Analysis First International Workshop, OMIA 2014, Held in Conjunction with MICCAI 2014, p.105-112

Cuffless BP

  1. Joseph, J.; Nabeel, P.M.; Sivaprakasam, M., “A calibration free method for cuff less evaluation of pulse pressure,” To appear in 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015

iQuant

  1. Joseph, J.; Chowdhury, K.B.; Sivaprakasam, M., “Image based quantitative reader for lateral flow immunofluorescence assay,” To appear in 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015

PPG, MPG, Other academic

  1. Nair, A; Ramanarayanan, S.; Ahlawat, S; Koushika, S; Joshi, N; Sivaprakasam, M., “Axonal transport velocity estimation from kymographs based on curvilinear feature extraction and spline fitting,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  2. Karthik, S.; Joseph, J.; Sivaprakasam, M., “A Study on the use of PPG in Quantifying Circulatory Disruptions,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  3. Preejith, S.; Joseph, J.; Sivaprakasam, M., “An Ocular Compression Device for Reduction of Elevated Post Anesthetic Intra Ocular Pressure,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  4. Nabeel, P.M.; Joseph, J.; Sivaprakasam, M., “Magnetic plethysmograph transducers for local pulse wave velocity measurement,” Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  5. Chandrasekhar, A.; Joseph, J.; Sivaprakasam, M., "Local Pulse Wave Velocity Estimation Using Magnetic Plethysmograph," Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, vol., no., pp.2287,2290,1172, 3-7 July 2013
  6. Chandrasekhar, A.; Joseph, J.; Sivaprakasam, M., "A novel magnetic plethysmograph for non-invasive evaluation of arterial compliance," Engineering in Medicine and Biology Society (EMBC), 2012 34th Annual International Conference of the IEEE, vol., no., pp.1169,1172, 28 Aug.-1 Sept. 2012